Palmitoylethanolamide (PEA) is a fatty acid that is naturally produced by the body in response to inflammation and pain. This fatty acid is known as a peripherally-acting pain reliever. This is because PEA is produced in the body on-demand and works at the site of injury or tenderness to lower inflammation and turn off the pain signal. Although the body makes PEA, supplementing with this naturally occurring fatty acid may help target the underlying cause of pain in a variety of pain states.
Acetaminophen and non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used as first-line treatment for pain. However, they are not free of side effects and long duration use can be dangerous. As such, safer alternatives are needed. PEA has an established safety profile and, unlike NSAIDs, has no documented negative impact on cardiovascular or organ health.